Protein Purification
MilliporeSigma™ Calbiochem™ SB 203580, Hydrochloride
SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC50 = 34nM in vitro, 600nM in cells).
MilliporeSigma™ Calbiochem™ InSolution™ STAT3 Inhibitor III, WP1066
The InSolution™ STAT3 Inhibitor III, WP1066, also referenced under CAS 857064-38-1, controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Swinholide A, Theonella swinhoei
A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro.
MilliporeSigma™ Calbiochem™ Ro-31-7549, Monohydrate
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
MilliporeSigma™ Calbiochem™ RNA Polymerase III Inhibitor
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC50 = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively).
MilliporeSigma™ Calbiochem™ InSolution™ SB 203580
InSolution SB 203580, CAS 152121-47-6, is a 1mg/mL solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC50 = 34nM in vitro, 600nM in cells).
MilliporeSigma™ Calbiochem™ γ-Secretase Substrate, Fluorogenic
An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase.
MilliporeSigma™ Calbiochem™ SHIP1 Inhibitor, 3AC
The SHIP1 Inhibitor, 3AC controls the biological activity of SHIP1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor, AGK2
The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor II, AK-1
The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac
The Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac controls the biological activity of Sialyltransferase.
MilliporeSigma™ Calbiochem™ Sirtinol
A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1.
MilliporeSigma™ Calbiochem™ Smad3 Inhibitor, SIS3
Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.
MilliporeSigma™ Calbiochem™ Smoothened Agonist, SAG
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
MilliporeSigma™ Calbiochem™ SIRT1/2 Inhibitor IV, Cambinol
The SIRT1/2 Inhibitor IV, Cambinol, also referenced under CAS 14513-15-6, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.